A: Methadone & buprenorphine/naloxone will not rot your teeth. However, one of the side effects of these medications is dry mouth. Having a dry mouth can increase the amount of bacteria in your mouth and if you have any pre-existing cavities, cracks or chips in your teeth it will cause the situation to become worse. We encourage all patients to see a dentist, practice good oral hygiene and to keep their mouth moist.